Knowledge workers in product design and development engineering depend on well-organized operations that enable lean innovation and agile processes that focus on customer value interests. Ken Bonenberger will describe a NPD&E paradigm for organizing innovation and customer focus called the Value Stream Matrix. This matrix comprises engineering functions and value streams. It poses Opportunities for operational excellence and innovation. It simultaneously gives rise to Challenges and Constraints for knowledge worker Collaboration. Ken Bonenberger presents the VS Matrix system elements. This is a bench mark discussion of the pros/cons, drivers/constraints inherent in adapting a value stream matrix system and its elements.